Not surprisingly, due to the emerging physiological roles of SFPQ in neuronal development and homeostasis as described above, an increasing number of recent literature has demonstrated the implications of SFPQ in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) frontotemporal lobar degeneration (FTLD), and Alzheimer’s disease (AD) [60,61,62,63,64]. This evidence concerns the gene SFPQ and early-onset autosomal dominant Alzheimer disease.