TARDBP and amyotrophic lateral sclerosis: In a follow-up study, the authors further demonstrated the biological link among SFPQ/FUS, tau isoform alteration, and FTLD-like phenotypes [64], where the examination of postmortem samples from patients of FTLD-spectrum diseases revealed impaired intranuclear colocalization of SFPQ and FUS in neurons of FTLD-spectrum cases including FUS-related ALS/FTLD, TDP-43-related ALS/FTLD (Figure 3c).