MYC and cancer: Many transporters and enzymes involve in glucose uptake and metabolism, e.g., glucose transporters (GLUTs), monocarboxylate transporters, hexokinase 2, lactate dehydrogenase A, and pyruvate dehydrogenase kinase 1, and transcription factors that regulate their expression, e.g., hypoxia inducible factor-1 alpha (HIF-1α) and c-myc, are overexpressed in various cancers [36,37,38,39,40,41,42].