However, Koetjapic acid, a natural triterpenoid, induced apoptosis in HCT 116 colorectal carcinoma cells by activating both the extrinsic and intrinsic caspases, which increased the hypoxia-inducible factor (HIF)-1α, mitogen-activated protein (MAP)/extracellular signal-related kinase (ERK)/JNK, and Myc/Max signaling pathways and decreased the nuclear factor (NF)-κB signaling pathway [34]. Here, MAPK8 is linked to colorectal carcinoma.