EVs containing meteorin-like protein, which has been shown to stimulate energy expenditure, improve glucose tolerance and increase expression of a number of anti-inflammatory cytokines [210], and IL-10 may provide benefits to the brain by directly regulating inflammation; activating microglia and astrocytes; and modulating peripheral inflammation, which has been shown to correlate with cognitive deficits in mild cognitive impairment and AD [211,212,213,214]. Here, METRNL is linked to Alzheimer disease.