Of note, tumour cells express a range of chemokines including CXCL2, CXCL5 and others [84] that facilitate recruitment of neutrophils to the TME through CXCR1 and CXCR2, and high levels of CXCL5 are expressed in a murine model of hepatocellular carcinoma (HCC) and correlate with poor prognosis in human HCC patients [88]. This evidence concerns the gene CXCR1 and hepatocellular carcinoma.