At HCC diagnosis, median CYFRA 21-1, AFP, and PIVKA-II levels were 1.3, 95% confidence interval (CI) 1.2–1.5 ng/mL, 12.6, 95% CI 8.6–16.9 ng/mL, and 199, 95% CI 146–316 mAU/mL, respectively. Here, AFP is linked to hepatocellular carcinoma.