(6) Other pathways in our result (Fig 4B) were indirectly linked to depression, in terms of nerve growth and inflammation, such as FoxO signaling pathway [70, 71], Jak-STAT signaling pathway [72, 73], prolactin signaling pathway [74, 75] and TGF-beta signaling pathway [76, 77]. Here, PRL is linked to depressive symptom measurement.