Similar to what was observed during infection with fadE2-, sucg-1(osa2) completely suppressed the extension in host survival conferred by valine (S11G Fig; p-value 0.808) and leucine (S11H Fig; p-value 0.461) during infection with wild-type P. aeruginosa. Therefore, valine and leucine promote host survival during P. aeruginosa infection via pathways related to host energy metabolism and UPRmt activation. Here, ARID1B is linked to infection.