LSM14A and viral infectious disease: Our studies indicated that LSM14A cleavage is mediated by 2Apro (Fig 3) at a recognition site with a P1 ́ G. To validate this target site, we changed the P1 ́ glycine (G147) to either alanine (A) or glutamate (E) and tested if these mutants were cleaved upon virus infection (Fig 6A).