PTGS2 and ischemic stroke: As for COX-2-8473T>C, Maguire et al. [40] demonstrated a significant effect of the COX-2-8473T>C polymorphisms on ischemic stroke functional outcome in Australians, while no association between the COX-2-8473T>C polymorphisms and intracerebral hemorrhage was observed in Koreans [41].