It has been shown that the COX-2-765G>C polymorphism is a protective factor against ischemic stroke in Italians [34], but the association between COX-2-765G>C and ischemic stroke and leukoaraiosis could not be replicated in Chinese [27, 38] and Koreans [39]. The gene discussed is PTGS2; the disease is Abnormal cerebral white matter morphology.