CD8A and neoplasm: Making use of the ovalbumin-derived peptide SIINFEKL (OVA 257–264) as a model antigen, the aim of this study was to explore in a comprehensive in vitro approach the potential of CNPs of different sizes and qualities as antigen delivery system to induce proper activation of antigen-specific CD8+ T cells by DCs and subsequent T cell-mediated tumor cell lysis.