Our study clearly suggests CNPs particularly of small size as most potent antigen vehicle because we could demonstrate that i) CNPs are efficiently taken up by DCs, those APCs that are necessary for priming and activation of CD8+ T cells, ii) CNP delivered antigen is presented in the context of MHC-I by DCs, iii) DCs stimulated with CNP-loaded antigen lead to activation and expansion of tumor antigen-specific CD8+ T cells and finally to induction of a potent anti-tumor response. This evidence concerns the gene CD8A and neoplasm.