This study found that the expression of UBE2I, CEBPD, and DSG2 in glioma tissues and cells was significantly increased, and was significantly negatively correlated with the survival prognosis of glioma patients, while the expression of PUM2 was significantly decreased, and was significantly positively correlated with the survival of glioma patients. The gene discussed is UBE2I; the disease is glioma.