In a recent study performed by Lo Russo et al,130 the infiltration of M2‐like CD163+CD33+PD‐L1+ clustered epithelioid macrophages was observed in tissue samples from 39 NSCLC patients with HPD after PD‐1/PD‐L1 blockade as well as in tumor lesions from immunodeficient mice inoculated with patient‐derived xenografts and human lung cancer cells. This evidence concerns the gene CD274 and lung cancer.