Terkeltaub Terkeltaub RA RA Furst Furst DE DE Digiacinto Digiacinto JL JL Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 3A4/P-glycoprotein inhibitors Arthritis Rheum Arthritis Rheum 2011 2011 63 63 11 11 3521 3521. The gene discussed is ABCB1; the disease is Arthritis.