One of the most important cytokines in the periodontitis-related immune response and tissue destruction is interleukin (IL)-1β, which is produced by macrophages, monocytes, lymphocytes, epithelial cells, fibroblasts, and osteoblasts,8 has a potent pro-inflammatory function,8 and is reported to be present in increased levels in the serum, saliva, and gingival crevicular fluid (GCF) of periodontitis patients when compared to controls.9 The gene discussed is IL1B; the disease is periodontitis.