Our results are supported by a previous study where TOL activates the nuclear factor erythroid 2‐related factor 2/heme oxygenase (Nrf2/HO‐1) antioxidant pathway through phosphorylation of protein kinase RNA‐like endoplasmic reticulum kinase (PERK) in rodent models of chronic kidney disease.46 This evidence concerns the gene EIF2AK3 and chronic kidney disease.