SH2D3A and infection: Upon infection, SARS-CoV-2 hijacks host cell translation machinery to synthesize ORF1a and ORF1b polyproteins that are subsequently proteolytically cleaved into 16 mature non-structural proteins, namely Nsp1 to Nsp16 (Chan et al., 2020a; Hartenian et al., 2020; Zhou et al., 2020).