SOD1 and amyotrophic lateral sclerosis: Defects in axonal organization and disrupted transport have been suggested to be another effect of SOD1 toxicity that could potentially lead to motor neurons death in ALS.72 Moreover, by interfering with the axonal transport machinery, SOD1 toxicity may indirectly impair the distribution of mitochondria to the periphery or impede retrograde delivery of trophic factors.73