SOD1 and amyotrophic lateral sclerosis: Indeed, when it comes to SOD1 pathology, the evidence so far converges toward a consensus which suggests the presence of enhanced activation of the AMPK energy sensor in both cell lines and animal models of disease,164,168 as well as ALS patients.165 Surprisingly, however, stimulation of AMPK signaling in SOD1 models has led to conflicting results.