In addition, we will also discuss how the contribution of TDP-43 pathology to energy imbalance differs to that of other well-known genetic causes of ALS such as the superoxide dismutase (SOD1) gene, chromosome 9 open reading frame 72 (C9orf72) gene and fused in sarcoma (FUS). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.