All prior investigations into the effect of T1D on BTMs have relied on cross‐sectional comparisons of resting concentrations against either healthy controls or those with type 2 diabetes, with a paucity of cohort studies.(27, 28, 29, 30) Additionally, most comparisons of BTMs have been in children and adolescents, with the aim of associating hyperglycemia with impaired bone accrual and increased risk of fracture in T1D.(27) We measured several markers of bone turnover to gain a more comprehensive understanding of the acute effect of exogenous insulin on bone remodeling. The gene discussed is INS; the disease is type 1 diabetes mellitus.