INS and type 1 diabetes mellitus: There is evidence in preclinical models that bone and pancreatic β‐cells are linked by a feedback loop by which osteocalcin (OCN) promotes β‐cell production and secretion of insulin.(12) Insulin then promotes the secretion of OCN, but this feedforward loop between the pancreas and the skeleton may be impaired with T1D due to a lack of pancreatic β cell function.