Therapeutic benefits of different VVs deleted of the TK gene have been reported in human mesothelioma xenograft mouse models,6,8 as well as in syngeneic mesothelioma mouse models.14, 15, 16 The failure of VVTK-RR-/GFP to totally cure the mice in our study may be due to the absence of an adaptive immune system that should enhance the oncolytic efficacy by the induction of an antitumor immune response. Here, TKT is linked to mesothelioma.