HSPG2 and neoplasm: In its soluble form endorepellin has been demonstrated to be anti‐angiogenic in endothelial cell and mouse tumor models, but conversely was pro‐angiogenic in the brain following ischemic injury.[18b] We have expressed a slightly longer human perlecan C‐terminal sequence (Leu3626 to Ser4391) that results in a recombinant proteoglycan form of domain V (rDV)[12, 18, 19] and is investigated in the current study.