TEX10 promotes RELA occupancy at gene promoters and regulates the expression of a subset of RELA‐targeted genes, including TNFAIP8, SAT1, and IL6ST. Taken together, this study identifies that TEX10 promotes the proliferation of CRC cells in an RELA‐dependent manner. Here, TNFAIP8 is linked to colorectal carcinoma.