It is clear that a growing body of work supports that impaired hippocampal adult neurogenesis underlies cognitive dysfunction observed in AD.[16] Preclinical studies show that the enhancement of endogenous neurogenesis and neuronal plasticity can reverse cognitive impairment.[17, 18] To explore whether hUC‐MSCs affected endogenous neurogenesis, we analyzed the coronal hippocampal sections of mice for proliferative Nestin+ and SOX2+ stem cells. Here, SOX2 is linked to Cognitive impairment.