Collectively, the data demonstrated that the core functional factor HGF secreted from hUC‐MSCs plays important roles in hUC‐MSC‐modulated recovery of damaged neural cells by down‐regulating hyperphosphorylated tau, improving the NFT, reversing spine loss, and promoting synaptic plasticity in the hippocampus of AD mice, which are all closely associated with memory deficits. Here, MAPT is linked to Alzheimer disease.