Immunofluorescent staining showed that the tumor treated with ICG‐PtMGs@HGd exhibited significant lower content of HIF‐1α compared to the one treated with saline or ICG‐MGs@HGd (Figure 5a), suggesting that the hypoxia of the tumor tissue was successfully alleviated due to the catalytic effect of Pt enzyme. Here, HIF1A is linked to neoplasm.