39-2.94]; III vs I1: HR = 3.80, 95% CI [2.39–6.02]) and high Gal-3 expression (HR = 1.64, 95% CI [1.11–2.42]) were associated with poor HCC prognosis, and differentiation moderate/well (HR = 0.61, 95% CI [0.43–0.86]) was positively associated with the overall survival rate of patients with HCC, while no relationship was showed between Gal-9 expression and survival (HR = 1.25, 95% CI [0.90–1.73]). The gene discussed is LGALS9; the disease is hepatocellular carcinoma.