Here, we studied the antigen specificity and phenotype of EBV-specific CD8<sup>+</sup> T cells in blood and tumor of one LELC patient positive for EBV infection in lung tumor cells.<h4>Methods</h4>Using multiplex MHC class I tetramers, mass cytometry and mRNA sequencing, we studied EBV-specific CD8<sup>+</sup> T cells at the transcriptomic and phenotypic levels in blood and tumor tissues of the LELC patient.<h4>Results</h4>Lymphoepithelioma-like carcinoma lung tumor cells were positive for EBV infection. This evidence concerns the gene CD8A and Epstein-Barr virus infection.