PTPRC and neoplasm: In a tumor model of M38 colon cancer, up to threefold increase in the level of monocytic Ly6Chi myeloid cells (CD11b+) among total CD45+ cells was found in irradiated tumor (20 Gy) compared to shame irradiation control 3 days after radiotherapy, suggesting Ly6Chi myeloid cells may alter the inflammatory profile in the TME and therefore may reduce the antitumor effects of radiotherapy.56