Those CD8+ T cells were activated, with higher TNF‐α+ CD8+ T cells, IFN‐γ+ CD8+ T cells and IL‐2+CD8+ T cells along with reduced frequencies of Tregs after SRT, suggesting hypofractionated SRT increased cytotoxic activities of immune cells, and down‐modulated immune suppressive cells, leading to reduced tumor growth.65 This evidence concerns the gene TNF and neoplasm.