Additionally, inhibitory receptors such as PD‐1, CTLA‐4, glucocorticoid‐induced TNFR family‐related gene (GITR), T‐cell immunoglobulin and mucin domain‐containing‐3 (TIM‐3), and lymphocyte‐activation gene 3 (LAG‐3) were also reported to upregulate on CD4+ and CD8+ T cells in many animal and human cancer studies with radiotherapy doses ranging from 1.8 to 30 Gy.32, 33, 77, 89, 90. This evidence concerns the gene CD4 and cancer.