In a tumor model of M38 colon cancer, up to threefold increase in the level of monocytic Ly6Chi myeloid cells (CD11b+) among total CD45+ cells was found in irradiated tumor (20 Gy) compared to shame irradiation control 3 days after radiotherapy, suggesting Ly6Chi myeloid cells may alter the inflammatory profile in the TME and therefore may reduce the antitumor effects of radiotherapy.56 This evidence concerns the gene ITGAM and neoplasm.