TNF and neoplasm: In a murine model of spontaneous insulinoma, low‐dose irradiation (2 Gy) in late‐stage tumor Rip‐Tag5 mice induced M1 TAM‐associated cytokines (e.g. TNF‐α, IL‐12p70 and IFN‐γ), and suppressed p38 mitogen‐activated protein (p38MAPK), leading to the acquisition of M1 macrophage phenotype.40