The strengths of this study include that it demonstrated the effect of fish oil/telmisartan combination on PCOS, and assessed the role of the glycemic control, steroid hormones, oxidative stress, TGF‐B1, NF‐kB, apoptosis, and Nrf2/HO‐1 signaling pathway in PCOS. The gene discussed is NFKB1; the disease is polycystic ovary syndrome.