Also, activation of Nrf2/HO‐1 pathway was reported to ameliorate the pathogenic sequelae of oxidative stress in PCOS which was in the same line with the results of the present study where both telmisartan and fish oil were able to increase Nrf2/HO‐1 content with amelioration of the characteristic features of PCOS in rats treated with DHEA. The gene discussed is HMOX1; the disease is polycystic ovary syndrome.