Instead, these congeners activate other receptors (e.g. peroxisome proliferator-activated receptors (PPAR)-α/γ, G-protein coupled receptors (GPR) 55, 110, 119, TRPV1 channels), which, unlike CB1, are known to counteract metabolic disorders in animal models3–5. The gene discussed is TRPV1; the disease is Other metabolic disease.