Intriguingly, we found that total and visceral fat mass are associated with elevated levels of lipid mediators known to activate a wide range of receptors that are associated with likely detrimental (i.e. CB1) and beneficial (e.g. GPR55, GPR119, PPARs, TRPV1) actions in the context of metabolic diseases. The gene discussed is GPR55; the disease is Other metabolic disease.