Two associated disorders have been identified, namely: fragile X-associated tremor/ataxia syndrome (FXTAS) that occurs in 45% of male PM carriers and 16% of female PM carriers after age 502,3 and fragile X-associated primary ovarian insufficiency (FXPOI) that affects 16–20% female PM carriers before age 40. This evidence concerns the gene PSMB5 and fragile X-associated tremor/ataxia syndrome.