DES and Hepatic fibrosis: Genes known to be upregulated in cholestasis-induced hepatic fibrosis, including desmin and αSMA markers of HSC, as well as structural proteins of extracellular matrix (ECM) such as collagen types I and III, and integrins, were tested in Mdr2KO mice and FVBN controls treated with vehicle, DG or Ghr (Fig. 6).