PDCD1 and Hepatic fibrosis: Importantly, when compared to F0/1, F3 liver fibrosis score was associated with higher percentage of CD4+PD-1+ T-cells (regression coefficient 5.69, 95% CI 0.13 to 11.26, P = 0.045), but the opposite was true in case of CD4+Tim-3+ T-cells (regression coefficient − 3.4, 95% CI − 6.66 to − 0.30, P = 0.032 for F2 and regression coefficient − 5.20, 95% CI − 9.09 to − 1.31, P = 0.010 for F3).