Pretreatment exhaustion markers expression correlated with liver fibrosis score: the more advanced fibrosis, the higher percentage of CD4+PD-1+ T-cells (median 20.1% (range 7.0–52.7%) in F0/1 vs 25.4% (8.8–43.8%) in F2 vs 26.8% (15.0–38.4%) in F3, P = 0.0125). The gene discussed is CD4; the disease is Hepatic fibrosis.