A robust tumor development was observed in all models; KrasG12D;Trp53−/− (Fig. 4b), KrasG12D;Stk11−/− (Supplementary Fig. 4Aa) and KrasG12C;Trp53−/− (Supplementary Fig. 4Ba) each with slightly different attributes (Table 2). Here, STK11 is linked to neoplasm.