HELLS and central nervous system cancer: Previous studies have reported that LSH could be involved in regulating stem cell-like characteristics and is an important modulator during early stem cell differentiation, functioning as a DNA methylation modifier.67 More interestingly, LSH is reported as an essential factor that could be implicated in boosting stem-like characteristics and tumorigenesis of skin cells and glioma cells.22,23 Nevertheless, the molecular and regulatory mechanisms responsible for modulating LSH activity to regulate stem cell characteristics are still not thoroughly clarified.