HELLS and neoplasm: Consistent with the results obtained from in vitro experiments, an in vivo study demonstrated that ectopic expression of the LSH R309A mutant increased tumor incidence, size as well as weight relative to LSH WT and Vector control, whereas the LSH S503A mutant exhibited reduced efficiency in terms of tumor formation and decreased tumor size and weight versus LSH WT (Fig. 7a and Supplementary Fig. S6a, b).