APOE and Alzheimer disease: When excluding APOE variants, the PRS was still significantly associated with an increased risk of AD and, in the opposite direction, with increased risk of resilience against AD (A vs. P: OR = 1.30, 95% CI = [1.22–1.40], p = 3.1 × 10−14 and C vs. P: OR = 0.78, 95% CI = [0.69–0.89], p = 2.4 × 10−4) (Fig. 1b and Supplementary Table S11).