APOE and Alzheimer disease: We found that the PRS, when including APOE variants, significantly associated with an increased risk of AD and, in the opposite direction, with increased chance of resilience against AD (A vs. P: OR = 2.61, 95% CI = [2.40–2.83], p = 8.4 × 10−113 and C vs. P: OR = 0.54, 95% CI = [0.45–0.65], p = 1.1 × 10−10) (Fig. 1a and Supplementary Table S11).