CXCR4 and infection: In order to investigate if either miR-103 or miR-107 influenced steps other than entry in MDMs, mimic-treated macrophages were infected with either CXCR4-tropic (Fig. 3B and C) or Env-negative (fig. 3D) HIV-1 that was VSV-G pseudotyped, thus limiting the analysis to a single round of infection.