BIN1 and centronuclear myopathy: BIN1 is mutated in different forms of centronuclear myopathies (CNM), characterized by muscle hypotrophy, muscle weakness, centralized nuclei and triad defects (Romero, 2010; Toussaint et al., 2011; Jungbluth and Gautel, 2014; Prokic et al., 2014).