Our results show that YAP/TAZ can positively regulate expression of Ctsk, Mmp2 and Mmp16 in addition to Ctgf and Cyr61. In particular, induction of Mmp16 along with Ctgf in the YAP5SAKI/+Col2a1cre+ve samples could contribute to the chondrodysplasia phenotype observed. This evidence concerns the gene CTSK and chondrodysplasia.