This concept is consistent with the known function of integrins in binding to the ECM and transducing signals via Hippo-YAP/TAZ in other tissues such as skin (Elbediwy et al., 2016), pancreas (Mamidi et al., 2018), tooth (Hu et al., 2017), blood vessels (Wang et al., 2016b), as well as in mesenchymal stem cells (Sabra et al., 2017; Tang et al., 2013), osteoblasts (Kaneko et al., 2014) and cancer cells (Kim and Gumbiner, 2015; Wong et al., 2016). This evidence concerns the gene WWTR1 and cancer.