In T-ALL, a vital role in Notch-driven thymocyte differentiation and leukemia has been assigned to mTOR complex 2, suggesting a potential role of mTOR C2 inhibition in undifferentiated T-ALL [47, 48]; however, activation of the PI3K axis is a common feature among T-ALL independent of differentiation stage. This evidence concerns the gene PIK3CD and acute lymphoblastic leukemia.