In acute leukemias PI3K/Akt signaling activity was demonstrated to be correlated with an inferior prognosis via contribution to proliferation, survival and drug resistance in acute myeloid leukemia [3, 10–12], in T-cell acute lymphoblastic leukemia (T-ALL) [13] and B-cell precursor acute lymphoblastic leukemia (BCP-ALL) [14–16]. The gene discussed is PIK3CA; the disease is T-cell acute lymphoblastic leukemia.