In contrast, the Treg frequency was statistically significant associated in the CREB expression (p < 0.0001): The higher the CREB expression of the tumor, the higher the amount of tumor infiltrating Tregs, although the mean absolute number of Tregs per high power field is rather low: non-CREB expressing tumors displayed 0.10 FoxP3+ immune cells per high power field in mean (median 0.00, std. Here, FOXP3 is linked to neoplasm.