As we have previously shown [9, 10], the t-Tau, phospho-Tau, and Aβ42 combination was very effective in discriminating between these two diseases (AUC = 0.95 for DLB-(pro+d) vs AD-(pro+d); Table 2), but unfortunately, the addition of α-syn did not improve this differential diagnosis (AUC = 0.95 for DLB-(pro+d) vs AD-(pro+d); Table 2); the same applies if Aβ42 is replaced by the ratio Aβ42/Aβ40 (t-Tau_phospho-Tau_Aβ42/Aβ40 AUC = 0.95; t-Tau_phospho-Tau_Aβ42/Aβ40_t-α-syn AUC = 0.95 for DLB-(pro+d) vs AD-(pro+d); Table 2). The gene discussed is MAPT; the disease is Lewy body dementia.