TLR2 and experimental autoimmune encephalomyelitis: In the murine model of MS, experimental autoimmune encephalomyelitis (EAE), the lack of TLR2 in CD4+ T cells was shown to ameliorate EAE [32], while inducing TLR2 tolerance via low-levels of a microbiome-derived TLR2 agonist resulted in amelioration of EAE [39].