METTL3 and malignant colon neoplasm: Compared with normal bowel tissues, METTL3, WTAP, YTHDF1, and IGF2BP3 were up-regulated, whereas METTL14, RBM15B, FTO, ALKBH5, YTHDF2, YTHDF3, YTHDC1, YTHDC2 were down-regulated in colon cancer (Fig. 1c).