As for the cognitive score of the ALS-CBS, the average score in normal controls was 15.67 ± 2.92 (mean ± SD, 50–59 years) and that in ALS patients was reported to be 14.66 ± 3.54 (mean ± SD, 50–59 years), while other reports that in ALS patients with frontotemporal dementia was 3.7 ± 3.4 in a previous report (mean ± SD) [25, 26]. The gene discussed is CBS; the disease is amyotrophic lateral sclerosis.