LAMB2 and Alzheimer disease: With respect to the AD samples (obtained from the parietal lobe), the ECM proteins laminin (Fig. 4a) and col IV (Fig. 4b) were significantly lower in MV from high ADNC brains relative to not ADNC brains (n = 12 per group, laminin p = 0.02 and col IV p = 0.03).