GLP1R and heart failure: SGLT-2i and GLP1-RA drugs showed a risk reduction in MACE of 10% and 14% in the subgroups of patients without prior heart failure [HR 0.90 (0.83–0.98), n patients = 3,185, and HR 0.86 (0.78–0.96), n patients = 7,497], and a 9-10% risk reduction among patients with prior heart failure [0.91 (0.73–1.14), n patients = 24,117, and 0.90 (0.79–1.02), n patients = 35,372], respectively (difference in effect between patients with vs. without heart failure: p = 0.652) (Additional file 1: Figure S3).