GLP1R and diabetes mellitus: In patients with uncontrolled diabetes (HbA1c > 8%), SGLT2i and GLP1-RA drugs reduced the risk of MACE by 16% [0.84 (0.75–0.95)] and 18% [0.82 (0.71–0.95)], respectively; while in patients with a better diabetes control (HbA1c ≤ 8%), the risk reduction was 8-9% [GLP1-RA: 0.91 (0.82–1.00); SGLT-2i: 0.92 (0.79–1.07)] (Fig. 4, p = 0.152).