Trends towards larger reductions in the risk of MACE were noted for SGLT2i drugs among patients with CKD compared to patients with mild or no impaired renal function, and for GLP1-RA and SGLT-2i drugs among patients with baseline HbA1c levels equal or greater than 8% compared to those with HbA1c levels less than 8%. This evidence concerns the gene GLP1R and chronic kidney disease.