GLP1R and cardiovascular disorder: By contrast, in 26,665 patients at high risk of cardiovascular disease, but without history of cardiovascular events, GLP1-RA and SGLT-2i seemed to have minimal or no effect on MACE [GLP1-RA: 0.94 (0.82–1.07); SGLT-2i: 1.00 (0.87–1.16)] (difference in effect between patients with vs. without a history of cardiovascular disease: p = 0.049, I2 = 74%) (Figure 2).