In addition to the anti-androgen actions of androgen inhibitors and AR antagonists aiming to reduce TMPRSS2 expression, direct TMPRSS2 blockers through serine protease inhibition have been proposed as potential drugs against COVID-19, including nafamostat, camostat, bromhexine, plasma alpha-1-antitrypsin, leupeptin [229–231]. The gene discussed is TMPRSS2; the disease is COVID-19.