While multiple mechanisms have demonstrated to participate in COVID-19 pathogenesis, the regulation of the Renin-Angiotensin-Aldosterone System (RAAS) has been demonstrated to be critical for the COVID-19 pathogenesis, since angiotensin 1–7 (Ang 1–7), ACE2 and AT1, that participate in the RAAS, are three of the four key modulators of SARS-CoV-2 infection patterns. The gene discussed is AGT; the disease is COVID-19.