MTOR and cancer: Among all the findings, down-regulation of CD274 caused by TXT and Ramucirumab in RELF-LC-A1 cells was unexpected results, because cellular stress response signals (i.e eIF2, NFkb, mTOR and OXPHOS) modulated by chemotherapeutic drugs are known to mostly up-regulate PD-L1 expression in cancer cells [21–23].