In addition, increased expression of tumor-associated genes, such as FPGS (folylpolyglutamate synthase)/GGH (gamma-glutamyl hydrolase) and VEGF (vascular endothelial growth factor), were found to be related to the degree of malignancy in thymic carcinoma and B3 thymoma [8]. The gene discussed is FPGS; the disease is thymic carcinoma.