For patients who are premenopausal, are older, have CINII+ results from TCT, have high parity, have high expression of TGFBR2, CSKN1A1, PRKCI, and CTBP2, and exhibit low expression of FOXO1, more attention should be paid to CIN progression. Here, FOXO1 is linked to cervical squamous intraepithelial neoplasia.