Overexpression of CTBP2 can also inhibit the expression of genes located downstream of the classic Wnt/β-catenin signaling pathway, such as CTNNB1 [34]; however, in this experiment, CTNNB1 was not inhibited by overexpressed CTBP2, indicating that the overexpression of CTBP2 might not promote the malignant transformation of cervical cells through Wnt/β-catenin signaling pathway, and it might use other pathways instead, leading to the occurrence and progression of CIN. This evidence concerns the gene CTNNB1 and cervical squamous intraepithelial neoplasia.